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Applegarth Dermatology PC

Serving the areas of Valparaiso and LaPorte, Indiana

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Patient Education

INSURANCES ACCEPTED:

*Please note these are our top companies that we participate with.  This is not a complete list.  Please contact your insurace carrier to verify whether or not we are in your provider network.

Traditional Medicare

Railroad Medicare

Sagamore

Cigna

Encore

United Healthcare

CHA

Coventry

CCN

First Health

Aetna

PHCS

Multi Plan

UMR

Lutheran Preferred

Indiana Health Network

Anthem BCBS PPO

Anthem BCBS PDS

Caresource - Medicare Plan

AARP Medicare Complete

IU Health Plans - Medicare and Commercial

Tricare

Anthem Medicare Advantage HMO

AMBETTER

EFFECTIVE 2/22/19: WE ARE NOW ACCEPTING ALLWELL

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Our team of professionals and staff believe that informed patients are better equipped to make decisions regarding their health and well-being. For your personal use, we have created an extensive patient library covering an array of educational topics, which can be found on the side of each page. Browse through these diagnoses and treatments to learn more about topics of interest to you.

As always, you can contact our office to answer any questions or concerns.

melanoma-treatments-helping-patients-live-longer.jpg
Reviewing x-ray: FDA-approved combinations of medications can shrink melanoma tumors and stop the cancer from spreading for a longer time.

If you have advanced melanoma, this means the cancer has spread. Surgery alone cannot remove the cancer. You’ll need other treatment.

One option that your doctor may talk about is combination therapy. It involves using two or more treatments at the same time to fight the cancer. This approach helps to attack the cancer in different ways.

One type of combination therapy is helping some patients with advanced melanoma. It involves taking two of the newer treatments for advanced melanoma. Results from clinical trials show that this approach can stop the cancer from spreading for longer than ever before. The combinations are also working for more patients, so more patients with advanced melanoma are living longer.

Receiving two drugs instead of one is also giving a few more patients complete clearing of their cancer. The number of patients with no sign of cancer, however, is still small.

Because of these breakthroughs, the U.S. Food and Drug Administration (FDA) has approved 3 combinations of these newer medications to treat advanced melanoma.

To be eligible to receive some of these approved combinations, the patient must have a BRAF-gene mutation. About half the people diagnosed with melanoma have a BRAF-gene mutation.

Your doctor can test you for a BRAF-gene mutation by taking a sample from a melanoma tumor.

FDA-approved combination therapies for advanced melanoma


Trafinlar® (dabrafenib) + Mekinsit® (trametinib)  
Type of treatment Targeted therapy
Patient must have a BRAF gene mutation Yes
How many patients had their cancer stop spreading, tumors shrink, or both 70%
Average time before cancer starts to spread again 12 months
Most common side effects Fever, chills, low white blood cell count
Type of medicine Pills - Most patients take dabrafenib twice a day and trametinib once a day.
How long patient takes the medicine As long as the medicine works or side effects cause the patient to stop taking the medicine.


Zelboraf® (vermurafenib) + Cotellic® (cobimetinib)
 
Type of treatment
Targeted therapy
Patient must have a BRAF gene mutation
Yes
How many patients had their cancer stop spreading, tumors shrink, or both
70%
Average time before cancer starts to spread again
12 months
(65% of patients were alive 17 months after starting the treatment)
Most common side effects
Diarrhea, sensitive to sunlight, nausea, fever, and vomiting
Type of medicine
Pills - Most patients take cobimetinib once a day for 21 days and then stop taking it for 7 days. They take vermurafenib twice a day without taking a break.
How long patient takes the medicine
As long as the medicine works or side effects cause the patient to stop taking the medicine.


Opdivo® (nivolumab) + Yervoy® (ipilimumab)
 
Type of treatment
Immunotherapy
Patient must have a BRAF gene mutation
No
How many patients had their cancer stop spreading, tumors shrink, or both
60%
Average time before cancer starts to spread again
8 to 9 months
(Some patients are alive more than 3 years after starting the treatment)
Most common side effects
Rash, itch, headache, vomiting
Type of medicine
Infusion - Patients go to a hospital or cancer treatment center, getting the infusions through an IV. Both infusions can be given on the same day.
When patients get the infusions
Most patients get the infusions once every 3 weeks for 12 weeks. Side effects may cause the patient to stop treatment early.

Tell your doctor about all the side effects

If you and your doctor decide that one of these combinations treatments is right for you, it’s important to pay attention to side effects. If you develop any side effect, tell your doctor immediately. Some side effects can be reversed if caught early, so you won’t have to stop treatment.

It’s also important for your doctor to know about all side effects because some can be quite serious. About 30% of patients stop treatment due to side effects.

How you’ll know if the treatment works

Your doctor will examine you often. You will also have medical tests. Scans can show whether the cancer is shrinking. Blood tests will tell your doctor how your body is reacting to the treatment.

Could this be a treatment option for you?

If you want to know whether one of these FDA-approved combinations might be an option for you, ask the doctor treating you for melanoma.


Image: Thinkstock

References
Duan L, Mukherjee EM, et al. “Tailoring the treatment of melanoma: Implications for personalized medicine.” Yale J Biol Med. 2015; 88(4):389-95.

Guo C, McQuade JL, et al. “Clinical, molecular and immune analysis of dabrafenib and trametinib in metastatic melanoma patients that progressed on BRAF inhibitor monotherapy: a phase II clinical trial.” JAMA Oncol. 2016; 2(8):1056-64.

Larkin, J, Ascierto PA, et al. “Combined vemurafenib and cobimetinib in BRAF-mutated melanoma.” N Engl J Med 2014; 371:1867-76.

Patel AB and Patterson S. (2017, March). Update on cutaneous reactions to targeted and immune cancer therapy. In Patel AB (Director), “Cutaneous adverse events to immune checkpoint inhibitor therapy.” Focus session presented at the Annual Meeting of the American Academy of Dermatology, Orlando, FL.

U.S. Food and Drug Administration [news releases]:

  • (November 10, 2015) “FDA approves Cotellic as part of combination treatment for advanced melanoma.” Lasted accessed February 15, 2017.
  • (January 10, 2014) “FDA approves Mekinist in combination with Tafinlar for advanced melanoma.” Lasted accessed February 15, 2017.

U.S. Food and Drug Administration. “Nivolumab in combination with ipilimumab.” [approved drugs]. Lasted accessed February 15, 2017.


Learn More

  • Acne
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Patient Education

Patient Education
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    • Eczema Bleach bath therapy
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  • Itchy skin
    • Bedbugs
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    • Psoriasis Skin Care Guide
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  • Skin cancer
    • Basal cell carcinoma
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    • Imiquimod: A treatment for some skin cancers, genital warts
    • Melanoma
      • Next steps after a melanoma diagnosis
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    • Skin cancer in people of color
    • Skin Cancer Prevention
    • Who's got your back
    • Can you spot skin cancer?
  • Skin, hair, and nail care
    • Skin care
      • How to Apply Sunscreen
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      • Skin Self-Exam: How to Do
      • Face Washing 101
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      • Get the most from your skin care products
      • Dry skin relief
      • Preventing skin conditions in athletes
      • How to care for tattooed skin
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      • How to Treat Diaper Rash
      • Skin Care on a Budget
      • How to Treat Boils and Styes
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      • How to Treat Hives in Children
      • Wrinkle Remedies
    • Hair care / hair loss
      • How to Style Hair Without Damage
      • Tips for Healthy Hair
      • How to remove gum without cutting hair
      • Coloring and perming tips
    • Injured skin
      • Tips for treating poison ivy
      • How to treat sunburn
      • Proper Wound Care: How to Minimize a Scar
      • How to Prevent and Treat Frostbite
    • Nail care
      • Manicure and pedicure safety
      • Tips for Healthy Nails
  • Other conditions
    • Diabetes warning signs
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Our Location

1861 S. Sturdy Rd
Valparaiso, IN 46383
(219) 548-0360
 
3444 Monroe
La Porte, IN 46350
(219) 362-0161

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Appointment Request

Valparaiso, IN Dermatologist Applegarth Dermatology PC 1861 S. Sturdy Rd. Valparaiso, IN46383 (219) 548-0360 Dermatologist in Valparaiso, IN Call For Pricing
La Porte, IN Dermatologist Applegarth Dermatology PC 3444 Monroe St. La Porte, IN46350 (219) 362-0161 Dermatologist in La Porte, IN Call For Pricing
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